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Antiproliferative, and anti-Topoisomerase I and II activities of the purified AME of A. alternata. A , The anti-proliferative activity of the purified AME towards the different cell lines (MCF7, HepG-2 cells,Caco2, and normal OEC cells), compared to Taxol as a positive control. Kinetics of Topoisomerase I ( B ) and Topoisomerase II ( C ), inhibition at different concentrations of AME by A. alternata as shown from agarose gel (upper panel), and IC50 value (lower panel).

Journal: Scientific Reports

Article Title: Characterization of Alternaria alternata alternariol monomethyl ether with a potential antiproliferative activity by topoisomerases inhibition; molecular docking and dynamic simulations

doi: 10.1038/s41598-026-51757-8

Figure Lengend Snippet: Antiproliferative, and anti-Topoisomerase I and II activities of the purified AME of A. alternata. A , The anti-proliferative activity of the purified AME towards the different cell lines (MCF7, HepG-2 cells,Caco2, and normal OEC cells), compared to Taxol as a positive control. Kinetics of Topoisomerase I ( B ) and Topoisomerase II ( C ), inhibition at different concentrations of AME by A. alternata as shown from agarose gel (upper panel), and IC50 value (lower panel).

Article Snippet: The antiproliferative activity of purified AME was evaluated towards the liver carcinoma (HepG-2) (ATCC, HB-8065), breast carcinoma (MCF7) (ATCC, HTB-22), human colorectal carcinoma cell line (Caco-2) (ATCC, HTB-37), in addition to the Oral Epithelial Cells (OEC) by the MTT reagent .

Techniques: Purification, Activity Assay, Positive Control, Inhibition, Agarose Gel Electrophoresis

The cell viability percentage of the phenyl 1,2,3-triazoles–2-pyridylpiperazine derivatives 13–23 was measured across various cancer cell lines (a) HCT-116, (b) HePG-2, (c) MCF-7, and (d) WI38.

Journal: RSC Advances

Article Title: Click chemistry of phenyl 1,2,3-triazole–2-pyridylpiperazine hybrids: synthesis, targeted anticancer activity, molecular modeling and computational studies

doi: 10.1039/d6ra01413e

Figure Lengend Snippet: The cell viability percentage of the phenyl 1,2,3-triazoles–2-pyridylpiperazine derivatives 13–23 was measured across various cancer cell lines (a) HCT-116, (b) HePG-2, (c) MCF-7, and (d) WI38.

Article Snippet: The cell lines utilized included HCT-116, HepG-2, MCF-7, and WI38, all obtained from ATCC via VACSERA in Cairo, Egypt.

Techniques: